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The question of injecting microbiological preparations did, however, come up in a section on therapy titled “Injecting tuberculin and related kinds of bacterial preparations.” The bulk of the section discussed tuberculin, but did not draw a strong distinction between tuberculin and a vaccine meant to prevent tuberculosis infection. When UNICEF deliberated over the funding and nature of the campaign in March 1948, it was China that formally proposed to extend the work from Europe (as it had originally been conceived) to activities in Asia, Latin America, and Africa (Brimnes 2007, 411). Shanghai: Shangwu yinshuguan. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 1995. We review evidence for non-specific protection induced by BCG vaccination against viral infections, discuss possible mechanisms of action, and summarize implications for vaccination policies and vaccine discovery. 2019 Nov 29;10:2806. doi: 10.3389/fimmu.2019.02806. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. 2007. In 1928, after a 1926 Norwegian clinical trial found the vaccine to prevent tuberculosis in 80 percent of human subjects (Flower 2008, 45), the League of Nations declared that the oral BCG vaccine was safe. 1946. This article investigates efforts to prevent and control tuberculosis in Republican China, especially efforts to implement the Bacille Calmette-Guérin (BCG) vaccine as a preventive measure against the disease. Ren Yibi, ed. After Japan’s surrender, in the tumultuous later years of the Chinese Civil War (1945–1949), health administrators began to plan the implementation of BCG vaccination on a large scale in China for the first time. The air still carried with it dangerous bacilli. The Modern Epidemic: A History of Tuberculosis in Japan. For example, in 1942, staff members at the institute replaced asparagine, an ingredient in Sauton’s medium, with sodium glutamate, a common ingredient in Chinese cuisine (Liu and Guo 1949, 276). The quantity of purulent lymphadenitis is dependent from the vaccine-type; "normal" vaccines cause 0.3%, the BCG-Pasteur Intradermal P-Vaccine caused 7.5%! "Product Information. During the war, Japan’s Meiji government assumed a strong role in developing programs to control tuberculosis (Johnston 1995). These side effects may go away during treatment as your body adjusts to the medicine. Alrabiaah AA, Alsubaie SS, Bukhari EI, Gad A, Alzamel FA. What is BCG. In the absence of such infrastructure, an international intervention to vaccinate with BCG provided a means of controlling the spread of tuberculosis. He proposed the use of the National Vaccine and Serum Institute (formerly the National Epidemic Prevention Bureau until it was renamed in January 1946) as the first site for BCG vaccine production, and the establishment of a center for training technical personnel in production methods, followed by mobile laboratory units that could help distribute the vaccine in China’s interior. N.p. Some side effects may not be reported. Treatment with BCG can cause a wide range of symptoms.  |  In Beiping—as the city of Beijing was known from 1928 to 1949—physicians at Peking Union Medical College, the leading school of Western medicine in China established and run by the Rockefeller Foundation, established the Beiping jiehebing xueshe (Beiping Tuberculosis Study Society) in October 1932. During the early twentieth century, a host of epidemic diseases presented a crisis for the nascent Republic of China. “Guest editorial: BCG Vaccination for Tuberculosis Control in China.” Chinese Medical Journal 65 (9–10): 381–383. In October 1948, they returned to China with freeze-dried samples of the Danish strain of BCG. Shanghai to Paris, Paris to Chongqing: The Introduction of BCG to China. The microneedle vaccine patch induced … The Republican government classified certain illnesses as fading chuanranbing, and these diseases merited extensive investments of personnel and money. Over six months in Copenhagen, these researchers studied BCG vaccine production, standardization, and distribution. Although the campaign originally earmarked $500,000 for work in China, it ultimately spent only $27,191 there—yet most of this sum went toward a donation of laboratory equipment for production of BCG, in a departure from typical spending patterns on non-European countries that participated in the campaign (International Tuberculosis Campaign 1951, 19, 30–32). “Protective Vaccination against Tuberculosis with Special Reference to BCG Vaccination.” American Review of Tuberculosis 58 (3): 255–281. Wang claimed that none of those immunized fell ill with tuberculosis. [9] This statement is odd, given that BCG vaccination was never widely implemented in the American population. Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations.  |  “Mucosal Immunity Induced by Oral Administration of Bacille Calmette-Guérin.” In Mucosal Vaccines, edited by Hiroshi Kiyono, Pearay L. Ogra, and Jerry R. McGhee, 269–279. Hara wrote, “The effectiveness of tuberculin and other bacterial material preparation therapies (for instance, Bailai serum, Shiga’s sensitized tuberculosis vaccine material, and so on—they are all a kind of tuberculin and their use is not different), has not yet been widely accepted. Published materials show that efforts to introduce this vaccine during the early 1930s met with skepticism on the part of Chinese physicians and inaction on the part of the state. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: After you stop using this medicine, it may still produce some side effects that need attention. The campaign lasted until 1951 and eventually reached beyond Europe to India, the Middle East, and even Mexico and Ecuador. 2011. Introduction. Feijiehe zheng zaifa zhi yufang 肺結核症再發之預防 [Prevention of the reoccurrence of tuberculosis]. doi: 10.1016/j.chom.2017.12.010. Tongji yuebao 38: 18. Those who catch the disease may therefore live for many years, and transmit the disease to others, before developing the characteristic symptoms—such as cough expelling sputum or blood (or both), night sweats, fatigue, fever, and weight loss—that indicate the contraction of tuberculosis. Tuberculosis is caused by the tubercle bacillus (Mycobacterium tuberculosis), discovered in 1882 by German physician and microbiologist Heinrich Hermann Robert Koch. You may report them to the FDA. In the first decades of its rule, the government of the Republic of China deprioritized tuberculosis because it was a social disease: a consequence of poverty and urban labor conditions that could not be controlled with public health programs, especially given constraints of time, money, and human resources (Lei 2010, 254–255). This site complies with the HONcode standard for trustworthy health information: verify here. Pepper, Suzanne. Front Immunol. This ambiguity presented difficulties for the authors and translators of texts about tuberculosis in China, since the BCG vaccine was often discussed in the context of injected bacterial preparations that could prevent or treat disease. The immunization programs sponsored by the bureau laid the foundations for national disease control programs in the postwar and post-1949 periods, and brought together Chinese microbiologists with foreign colleagues involved in medical aid programs sponsored by groups like the League of Nations Health Organization and the American Bureau for Medical Aid to China (ABMAC) (Brazelton forthcoming 2019). 2004. In the case of tuberculosis, the ambiguous status of another biochemically produced substance, tuberculin (jiehe jun su 結核菌素), complicated acceptance and understanding of the BCG vaccine. Last updated on Jul 21, 2020. Lei, Sean Hsiang-lin. Zhang, Yixia, and Mark Elvin. BCG; Innate immune memory; Non-specific effects of vaccines; Trained immunity; Viral infection. Yet the report concluded that the upheaval of civil war meant that “it was not feasible to start the usual kind of ITC-aided BCG programme in China” (International Tuberculosis Campaign 1951, 46). BCG does not always protect people from getting TB. Their hesitation—often expressed in the assertion that preventive measures might include BCG but certainly ought to continue to stress social measures—also supported broader, environmental efforts to control tuberculosis by transforming local health infrastructures and personal, familial behaviors. As early as 1929, Chinese physicians traveled to Paris to acquire samples of BCG, launched urban pilot programs, and discussed the BCG vaccine in medical textbooks and handbooks—yet medical discussions of the vaccine in the 1930s remained tentative, casting it as a foreign pharmaceutical intervention of unclear efficacy and technical complexity, thereby preserving the identity of tuberculosis in China as a social disease best controlled through transformations of personal and environmental hygiene. Jacquerod, M. 1933. "Product Information. After completing their studies, the trio toured anti-tuberculosis projects in Norway, Switzerland, Italy, France, England, and the United States. It's important to leave the area uncovered as the air will help it to heal. Soon, Wayne S. 2016. "Trained immunity" from Mycobacterium spp. Some of these physicians and researchers—notably Tang Feifan, wartime head of the National Epidemic Prevention Bureau—had been involved in BCG research before the war broke out. HHS Moreover, the economic, social, and military crises of the Civil War were not conducive to qualitative improvements in working and living conditions in China’s cities and villages. Cities under Japanese occupation generally emphasized public health programming and, at least in the case of Tianjin, distributed vaccines against cholera, smallpox, and typhoid fever (Rogaski 2004, 272–273), but the BCG vaccine against tuberculosis does not seem to have been typically considered part of these interventions. The most common side effects include fever, headache and swollen glands. 2014. Portions of this document last updated: Nov. 01, 2020. 2018 Aug;13(10):1193-1208. doi: 10.2217/fmb-2018-0026. The International Tuberculosis Campaign did not directly sponsor tuberculin testing or BCG vaccination work in China, yet Chinese participants were involved in the project’s formation and evolution. In July 1921, the pediatrician Benjamin Weill-Hallé successfully gave an oral vaccine using live, attenuated tubercles to a Parisian infant (Gheorgiu 2011, 50; Liu et al. Yet the vaccine’s promotion in China before 1949, especially during the Civil War, was the result of attention to bacteriological research on a global stage, perceived connections between the prevalence of tuberculosis in China and its state of economic crisis, and a genuinely national vision for public health and immunization work. Despite this enthusiasm, Imamura went on to reserve final judgment, saying that “now it is just the problem of quality [literally, chengji 成績 (grades)], which still has not reached a definite judgment.” He concluded ambiguously, “It’s the most interesting vaccine in the world” (Imamura 1935, 173). This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 United States License, Mary Augusta Brazelton, University of Cambridge. During the late nineteenth and early twentieth centuries, urbanization and the rise of factory production in cities created crowded, unsanitary conditions that permitted infectious diseases like tuberculosis to spread rapidly in China. In advocating for the adoption of BCG as a critical preventive measure, authors discussed the precedents that other nations had set in producing and distributing the vaccine. So the danger of routineously made BCG-vaccinations in newborns got higher than the risk of Tbc-infections. They took the United States, rather than Japan, as a model of immunization practice, and they participated in transnational anti-tuberculosis health programs. Organon Pharmaceuticals, West Orange, NJ. NIH With the physician Lu Yongchun at its head, they raised funds to build a tuberculosis hospital that would include a sanatorium and public health department. [5] Hara’s text, aimed at medical students, again indicated the complex nature of the medical marketplace, the lack of international consensus on a bacteriological approach to controlling tuberculosis, and the fear that patients could easily misunderstand the nature of their disease and how best to treat or prevent it. BCG vaccine has been the "standard of care for patients with bladder cancer (NMIBC)" since 1977. Mass Vaccination: Citizens’ Bodies and State Power in Modern China. We comply with the HONcode standard for trustworthy health information -. Several years later, in 1935, the Beiping Number One Health Station (Beiping di yi weisheng shiwusuo)—a pioneering public health project of Peking Union Medical College in collaboration with a local police department—established a clinic dedicated to tuberculosis treatment and prevention that became a model for future programs. Consequently, a variety of substances related to tuberculin appeared on pharmaceutical markets and made standardization of the BCG vaccine extremely difficult, since “tuberculin was seen essentially as a vaccine” (Bonah 2008, 281). “Jibing zhishi, yiliao wenhua yu weisheng xiandaixing: Jindai Zhongguo feijiehebing de shehui yu wenhua shi (1850–1940 nian dai)” 疾病知识,医疗文化与卫生现代性:近代中国肺结核病的社会与文化史(1850–1940年代) [Knowledge of disease, cultures of healing, and hygienic modernity: The social and cultural history of tuberculosis in modern China (1850s–1940s)]. 1982. Global Dissemination and Chinese Promotion of BCG. While you are being treated with BCG, and for 6 to 12 weeks after you stop treatment with it, avoid contact with people who have tuberculosis. Objectives: Feijiehe bing (feilao) wenda yi qian ze 肺結核病 (肺癆) 問答一千則 [A thousand questions and answers about tuberculosis]. Keywords: tuberculosis, Bacille Calmette-Guérin, BCG, Republic of China, public health, bacteriology, vaccine, immunization, epidemic, Danger in the Air: Tuberculosis Control and BCG Vaccination in the Republic of China, 1930–1949. The Shanghai Pasteur Institute continued to distribute BCG vaccines after the city fell to the Japanese in 1937, and vaccinated a total of 5,661 people between 1937 and 1946. Future Microbiol. [10] Wang may have been drawing on the same research by Joseph Aronson that Wu Shaoqing had. “Project on BCG Vaccination for China.” Chinese Medical Journal 66 (10): 568–575. Even if BCG vaccine is shown to be effective, that’s no reason to stockpile. Although Cui, writing for a broader audience than Imamura, did not delve into the technicalities of immunology, he referred to multiple versions of an anti-tuberculosis vaccine, specifically versions produced in England and Japan. [BCG vaccination: characteristics of drugs and causes of vaccinal complications]. 1930. In the case of BCG, these processes bore fruit only in the years after the war ended, when a review of medical literature suggests that in the tumultuous years of civil war between 1945 and 1949, health administrators began to plan for implementation of the BCG vaccine on a large scale for the first time. The vaccine itself proved difficult to produce and implement, but its promotion reflected the transformations that war had wrought in China’s public health system, as well as the particular meaning that physicians gave to the economic implications of the tuberculosis crisis and their engagement with global networks of bacteriology.  |  [6] Original source: “如我國衛生當局,經專家檢定標準接種方法後再努力推行,始種牛豆[sic] 以防天花,則於國民健康和國家經濟殊有無限之影響.”, [7] Original source: “不能運至遠處施用,即在本地施用,必至拋棄甚多失效菌苗,大不經濟.”. “Vikings against Tuberculosis: The International Tuberculosis Campaign in India, 1948–1951.” Bulletin of the History of Medicine 81 (2): 407–430. 1996. While you are being treated with BCG and for a few weeks after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. This vaccine is not widely used in the United States, but it is often given to infants and small children in other countries where TB is common. Translated from the Japanese by Xie Yushou. Important lines of evidence indicating that BCG protects against viral pathogens comes from experimental studies in mice showing that BCG offers protection against various DNA and RNA … While you are being treated with BCG, and for 6 to 12 weeks after you stop treatment with it, avoid contact with people who have tuberculosis. 2011. Core, Rachel. 1935. Wang relied on global standards of assessment and especially on the authority of American biology to reassure Chinese readers that the vaccine worked. In the early twentieth century, while smallpox, cholera, and other diseases caused temporary but urgent health crises in China, pulmonary tuberculosis remained a leading cause of mortality. Most children develop a sore at the injection site. He first discussed the BCG vaccine, describing it simply as “French” and that it “used a kind of special method” to produce an attenuated bovine tubercle bacillus suitable for inoculation of infants younger than one week. Although the outbreak of the Second Sino-Japanese War (1937–1945) presented an obstacle to BCG research and development, it also provided new opportunities for members of China’s biomedical research community—many of whom had moved with the Nationalist government to the nation’s western hinterlands—to learn about new methods of producing vaccines and study methods of epidemic control. NIH 2020 Oct 2;11:579250. doi: 10.3389/fimmu.2020.579250. “A Distinctive Nation: Vaccine Policy and Prevention in Japan.” In The Politics of Vaccination: A Global History, edited by Christine Holmberg, Stuart Blume, and Paul Greenough, 209–235. “Environment and Tuberculosis in Modern China.” In Sediments of Time: Environment and Society in Chinese History, edited by Mark Elvin and Cuirong Liu, 520–542. It's a vaccine which is a type of immunotherapy medicine. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. 1998. Feilao bing ziji liaoyang fa 肺癆病自己療養法 [Methods of recuperating from tuberculosis oneself]. Translated by Hong Shilü. 1999. [HIV-infection, AIDS and BCG vaccination]. Hoft, Daniel F., and Marina Gheorghiu. 1997. Chen set up a laboratory at the National Vaccine and Serum Institute in Beijing to produce the vaccine, and Wei did likewise at the Shanghai branch of the Vaccine and Serum Institute (Chen, Wei, and Zhu 1982, 437–438). Rothman, Sheila M. 1995. Serious side effects from the BCG vaccine, such as a serious allergic reaction (anaphylactic reaction), are very rare. The latter might have been a preparation developed by the bacteriologist Shiga Kiyoshi; in 1924, Shiga had taken samples of BCG from the Paris Pasteur Institute to the Institute for Infectious Diseases in Tokyo (Yongue 2017, 212). BCG-sepsis. 1932. Content: 1936. Please enable it to take advantage of the complete set of features! Feldberg, Georgina. This site needs JavaScript to work properly. 2014. “The Specificity and Sensitivity of the Tuberculin Reaction Following Vaccination with BCG.” American Journal of Hygiene 33, section B (2): 42–49. Once healed, the sore may leave a small scar. If efforts to control tuberculosis in China during the Republican period were largely characterized by official neglect and professional concern, then the emergence of the BCG vaccine for the disease changed this calculus. See below for a comprehensive list of adverse effects. All staff who give vaccinations are trained to treat allergic reactions. The widespread dissemination of BCG remained an ideal solution to medical and economic problems rather than a feasible plan for public health in China. Outbreak of Bacille Calmette-Guérin-related lymphadenitis in Saudi children at a university hospital after a change in the strain of vaccine. 1947. The international health organizations that emerged in the wake of that war promoted BCG as a solution to this emergency. This work was centered chiefly, but not exclusively, in Kunming, where the National Epidemic Prevention Bureau (Zhongyang fangyi chu)—the chief governmental agency that took responsibility for manufacturing biological products in China—made its wartime headquarters. Hygienic Modernity: Meanings of Health and Disease in Treaty-Port China. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Imamura Arao. Lomisch. Fan, Joshua. Procedures for manufacturing the vaccine generally followed international norms—using a solution called Sauton’s medium—but the wartime institute changed these methods to adapt production to wartime scarcity. Shanghai: Shehui yibao guan. Covián C, Fernández-Fierro A, Retamal-Díaz A, Díaz FE, Vasquez AE, Lay MK, Riedel CA, González PA, Bueno SM, Kalergis AM. Watt, John Robertson. Tice BCG Vaccine (BCG (BCG vaccine))." Next review due: 23 April 2022, Booking your child's vaccination appointment. Animal Experimentation and Prophylactic Immunization of Children: An Analysis and Critical Review.” American Journal of Public Health and the Nation’s Health 18 (7): 843–864. In retrospect, Wang presented his research in France as a fundamentally patriotic endeavor: “Thinking of the needs of our nation to fight tuberculosis,” he wrote in 1948, “I traveled across the oceans, and went to Calmette’s laboratory” (Wang 1948, 13).[2]. A native of Chengdu, Wang had trained at the medical school at Hanoi established by the French colonial government of Indochina, then pursued medical studies in France before taking up a position as chief physician at the Ren’aitang yiyuan (Ren’aitang Hospital) in 1913. The Gospel of Germs: Men, Women, and the Microbe in American Life. This technical textbook did not mention the BCG vaccine in its section on prevention, where it instead focused on social means of preventing the disease. “People should not hoard or try to get BCG vaccine like they did toilet paper,” Otazu said. TB prevention and control would benefit from an improved method of BCG vaccination that simplifies logistics and eliminates dangers posed by hypodermic … 2018. Mayo Clinic does not endorse companies or products. Zhu, Hengbi [H. P. Chu]. 1948. Yet after news of the Lübeck incident spread to China, concerns about the safety of BCG forestalled its production and implementation, despite Song’s promotion of the vaccine in medical literature (He 2011, 117). Manchester, UK: Manchester University Press. Drug information provided by: IBM Micromedex. Important lines of evidence indicating that BCG protects against viral pathogens comes from experimental studies in mice showing that BCG offers protection against various DNA and RNA viruses, including herpes and influenza viruses. Get the latest public health information from CDC: Manifestations of disseminated infection may not develop for months or years after therapy as BCG may persist in the urinary tract for several months after treatment. Intimate Communities: Wartime Healthcare and the Birth of Modern China, 1937–45. Occasionally, there may be a more severe skin reaction, but this should heal within several weeks. TB Vaccine (BCG) Bacille Calmette-Guérin (BCG) is a vaccine for tuberculosis (TB) disease. 2020 Oct 29;16(10):e1008969. Heterologous effects of vaccination and trained immunity. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Song was the first, but far from the only, physician to bring BCG cultures to China. During this period of time, Check with your doctor immediately if you notice the following side effects: Applies to bcg: intravesical powder for reconstitution, percutaneous powder for injection, Very common (10% or more): Dysuria (60%), increased urgency/frequency (40%), drug induced cystitis (30%), bacterial cystitis (27%), hematuria (27%), pollakiuria, Common (1% to 10%): Urinary tract infection, urinary incontinence, micturition urgency, urine analysis abnormal, bladder cramps, hemorrhage cystitis, urinary retention, Uncommon (0.1% to 1%): Bladder constriction, pyuria, ureteric obstruction, Rare (0.01 to less than 0.1%): Epididymitis, Very rare (less than 0.01%): Orchitis, balanoposthitis, prostatitis, vulvovaginal discomfort[Ref], Very common (10% or more): Malaise/fatigue/lethargy (19%), fever without infection (13%), influenza-like illness, pyrexia, rigors, Very rare (less than 0.01%): Reiter's syndrome, chest pain, peripheral edema, prostate specific antigen increased, weight decreased, BCG osteomyelitis[Ref], Very rare (less than 0.01%): Dysesthesia, hyperesthesia, paresthesia, somnolence, headache[Ref], Uncommon (0.1% to 1%): Pancytopenia, thrombocytopenia, Very rare (less than 0.01%): Lymphadenopathy, Frequency not reported: Axillary or cervical lymphadenopathy, regional suppurative lymphadenitis[Ref], Common (1% to 10%): Abdominal pain, nausea, vomiting, diarrhea, Very rare (less than 0.01%): Dyspepsia, flatulence[Ref], Uncommon (0.1% to 1%): Tuberculosis infections, Very rare (less than 0.01%): Disseminated BCG infection[Ref], Uncommon (0.1% to 1%): Rashes, eruptions and exanthema not otherwise classified, Very rare (less than 0.01%): Lupus vulgaris, alopecia, hyperhidrosis, granuloma[Ref], Very rare (less than 0.01%): Pharyngitis, bronchitis, dyspnea, rhinitis[Ref], Very rare (less than 0.01%): Renal failure acute[Ref], Common (1% to 10%): Arthralgia, arthritis, myalgia, Very rare (less than 0.01%): Back pain[Ref], Common (1% to 10%): Allergic symptoms[Ref], Uncommon (0.1% to 1%): Hepatitis, hepatic enzyme increased[Ref], Very rare (less than 0.01%): Hypotension[Ref], Very rare (less than 0.01%): Confusional state[Ref], Very rare (less than 0.01%): Anorexia[Ref], Very rare (less than 0.01%): Conjunctivitis[Ref], Frequency not reported: Injection site reactions: Induration, pustule formation, ulceration, caseous lesions, purulent draining, tenderness, itching, papules[Ref], 1. Flanagan KL, Best E, Crawford NW, Giles M, Koirala A, Macartney K, Russell F, Teh BW, Wen SC. Feijiehe zhi zaoqi zhenduan 肺結核之早期診斷 [Early diagnosis of tuberculosis]. Chichester, UK: John Wiley and Sons. Although physicians continued to discuss the value of combining BCG vaccination with environmental and social measures, they gave new prominence to immunization as they stressed the potential of BCG to make the Chinese population healthier and more productive. The vaccine was created in 1796. Cerner Multum, Inc. "Australian Product Information." He Ling. Indianapolis: Indiana University Press. Feijiehe zhi changshi 肺結核之常識 [General knowledge of tuberculosis]. Shanghai: Yixue shuju. “B.C.G. However the vaccine should not be given to people who are clinically immunosuppressed (either due to drug treatment or underlying illness). “Medical Education during the Anti-Aggression War.” Chinese Medical Journal 64 (1–2): 17–23. Clin Microbiol Infect. Does the BCG vaccine for TB help with COVID-19 (coronavirus)? Mitinskaia LA, Demeshko ND, Efimova AA, Litseva OA, Iablokova TB, Levi DT, Pisarenko NN, Kogan ES. In regions under Nationalist control, the war was also a key period for the state development and large-scale manufacturing of immunizations against infectious diseases. Cambridge: Cambridge University Press. PhD diss., Université de Paris VII.

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